Born in the UK, Mark Dytham studied architecture at Newcastle University and the Royal College of Art in London. In 1989, he travelled with business partner Astrid Klein to Tokyo, and together they found work with Toyo Ito. They soon established Klein Dytham architecture, working freely across disciplines including architecture, interiors, furniture, installations, and events.

Dytham is a frequent guest speaker at international design events, and has taught at universities in Japan and beyond. In 2000, he was awarded an MBE (Member of the Order of the British Empire) for services to British Design in Japan.